Table 2.

miRNA in ovarian cancer tissue—animal model studies.

miRNA	Type of Ovarian Tissue	Changes in Ovarian Cancer
miR-23b	Nude mice injected subcutaneously with mock or hsa-miR-23b–transfected OVCAR3 cells	miR-23b induces downregulation of cyclin G1 (CCNG1) in tumor xenografts and reduction of tumor size in mice [46]
miR-26a	Nude mice injected subcutaneously with SKOV3 cells transfected with miR-26a or anti-miR-26a	miR-26a is involved in cell proliferation and tumor development in epithelial ovarian cancer induced in animal models [47]
miR-125b	Nude mice inoculated with SKOV3 cells that were transfected with the vector control, miR-125b mimic or inhibitor	miR-125b inhibits the in vivo cancer cell migration and invasion [48]
miR-125b	Nude mice injected subcutaneously with SKOV3 cells transfected with miR-125b or anti-miR-125b	miR-125b suppresses the development of ovarian cancer [49]
miR-141	BALB/cAnN nude mice injected intraperitoneal with stable SKOV3 miR-141-expressing clones, or A2780cp shSu knockdown clone and the scrambled controls	miR-141 increases tumor growth in vivo and induces the appearance of a great number of macroscopic tumor nodules, especially in the omentum and the peritoneal cavity [50]
miR-146b	Nude mice injected with control cells or cells overexpressing miR-146b	Overexpression of miR-146b reduces cell migration and decreases the level of F-box and leucine-rich repeat protein 10 (FBXL10) protein [53]
miR-337-3p	Xenograft models of ovarian cancer induced by inoculation of A2780 and OVCAR-3 cells in female BALB/c athymic nude mice	miR-337-3p is a tumor suppressor that controls the expression of p110α and p110β (i.e., PIK3CA and PIK3CB encoded proteins) [56] Tumors injected with miR-337–3p agomiR grew more slowly than those injected with agomiR-NC for both xenograft models [56]
miR-630	Balb/c mice injected subcutaneously with SKOV3 cells transfected with inhibitors, mimics or negative control of miR-630	miR-630 overexpression stimulates in vivo ovarian cancer proliferation [58]