Table 2.
Details of the MLN resistance associated SNP markers and their probable candidate genes identified in the large set of association mapping panel.
| SNP | Chr | Position (bp) | MLM P-Values | R2 | MAF * | Allele | MAE ** | Putative Candidate Genes | Predicted Function of Candidate Gene |
|---|---|---|---|---|---|---|---|---|---|
| MLN disease severity | |||||||||
| S1_44539940 | 1 | 44539940 | 9.66E-09 | 0.05 | 0.10 | C/T | 0.42 | GRMZM2G024159 | protein YIPF5 homolog |
| S1_281333891 | 1 | 281333891 | 8.46E-08 | 0.04 | 0.17 | C/G | 0.07 | GRMZM2G177046 | bZIP transcription factor |
| S3_147938951 | 3 | 147938951 | 8.93E-08 | 0.04 | 0.12 | C/G | −0.22 | GRMZM2G044867 | unknown |
| S3_149313702 | 3 | 149313702 | 2.50E-07 | 0.04 | 0.22 | A/G | −0.02 | GRMZM2G428168 | S-glutathionylation and deglutathionylation |
| S3_161574458 | 3 | 161574458 | 9.25E-07 | 0.04 | 0.09 | C/G | −1.97 | GRMZM2G145346 | PAK-box/P21-Rho-binding |
| S3_161574468 | 3 | 161574468 | 4.40E-07 | 0.03 | 0.11 | T/A | 0.73 | GRMZM2G145346 | PAK-box/P21-Rho-binding |
| S3_161574470 | 3 | 161574470 | 1.25E-06 | 0.03 | 0.09 | A/G | 0.75 | GRMZM2G145346 | PAK-box/P21-Rho-binding |
| S3_161574471 | 3 | 161574471 | 2.69E-07 | 0.04 | 0.09 | C/A | 0.8 | GRMZM2G145346 | PAK-box/P21-Rho-binding |
| S4_199711804 | 4 | 199711804 | 4.76E-07 | 0.04 | 0.29 | C/T | −0.11 | GRMZM2G134857 | uncharacterized protein |
| S7_140411743 | 7 | 140411743 | 4.84E-07 | 0.04 | 0.07 | C/T | 1.49 | GRMZM2G071015 | BAG-associated GRAM protein |
| S7_143109798 | 7 | 143109798 | 9.81E-07 | 0.03 | 0.37 | C/T | 0.71 | GRMZM2G179021 | RNA.regulation of transcription. |
| S7_166270242 | 7 | 166270242 | 5.95E-07 | 0.04 | 0.11 | G/C | 0.54 | GRMZM2G520980 | unknown |
| S9_9599125 | 9 | 9599125 | 5.21E-07 | 0.03 | 0.08 | A/C | 1.25 | GRMZM2G159402 | transcriptional activation |
| S9_149758216 | 9 | 149758216 | 4.94E-08 | 0.04 | 0.25 | T/C | 0.11 | GRMZM2G540298 | unknown |
| S10_3189860 | 10 | 3189860 | 4.97E-07 | 0.04 | 0.05 | A/G | −1.16 | GRMZM5G862857 | uncharacterized protein |
| S10_138075442 | 10 | 138075442 | 7.56E-07 | 0.03 | 0.26 | G/C | 0.77 | GRMZM2G117667 | GDSL-like Lipase/Acylhydrolase superfamily protein |
| S10_138075445 | 10 | 138075445 | 7.56E-07 | 0.03 | 0.26 | C/T | 0.77 | GRMZM2G117668 | unknown |
| S10_140985097 | 10 | 140985097 | 3.94E-07 | 0.04 | 0.08 | T/C | 0.06 | GRMZM2G109753 | scramblase family protein |
| Total R2 | 17.05 | ||||||||
| Area under disease progress curve | |||||||||
| S1_44539940 | 1 | 44539940 | 6.92E-16 | 0.1 | 0.1 | C/T | 10.15 | GRMZM2G024159 | Yip1 domain containing protein |
| S1_253798682 | 1 | 253798682 | 7.08E-07 | 0.03 | 0.33 | G/A | 23.06 | GRMZM2G043127 | translocase of the outer mitochondrial membrane |
| S2_28895383 | 2 | 28895383 | 1.86E-07 | 0.03 | 0.42 | A/G | 7.3 | GRMZM2G077420 | unknown |
| S3_33757503 | 3 | 33757503 | 7.85E-07 | 0.03 | 0.13 | T/C | −18.42 | GRMZM2G563119 | unknown |
| S3_55239348 | 3 | 55239348 | 5.33E-07 | 0.03 | 0.37 | C/G | 4.69 | GRMZM2G520940 | protein coding |
| S3_56468811 | 3 | 56468811 | 5.63E-09 | 0.04 | 0.43 | A/G | 3.02 | GRMZM2G409309 | powdery mildew resistant protein5 |
| S3_136082606 | 3 | 136082606 | 2.87E-07 | 0.04 | 0.39 | G/C | 32.3 | GRMZM2G092169 | uncharacterized protein |
| S3_147938951 | 3 | 147938951 | 1.04E-07 | 0.04 | 0.12 | C/G | −0.22 | GRMZM2G044867 | unknown |
| S3_190890553 | 3 | 190890553 | 9.37E-07 | 0.03 | 0.15 | G/A | 1.6 | GRMZM2G563190 | mitochondrial electron transport/ATP synthesis. |
| S4_199711804 | 4 | 199711804 | 1.89E-19 | 0.12 | 0.29 | C/T | −2.87 | GRMZM2G134857 | uncharacterized protein |
| S4_200034077 | 4 | 200034077 | 3.06E-07 | 0.03 | 0.16 | A/G | 12.07 | GRMZM2G465165 | ATP binding/amino acid phosphorylation |
| S5_182091386 | 5 | 182091386 | 8.77E-07 | 0.03 | 0.25 | T/A | 39.18 | GRMZM2G137426 | protein dimerization activity |
| S6_99770682 | 6 | 99770682 | 1.04E-06 | 0.03 | 0.39 | T/G | 22.51 | GRMZM2G112337 | MAP65-2 microtubule-associated protein |
| S6_148513637 | 6 | 148513637 | 8.16E-07 | 0.03 | 0.07 | A/G | 47.5 | GRMZM2G020856 | O-fucosyltransferase family protein |
| S7_8677545 | 7 | 8677545 | 1.16E-08 | 0.05 | 0.24 | C/G | −10.84 | GRMZM2G107408 | uncharacterized protein |
| S7_168745410 | 7 | 168745410 | 3.55E-07 | 0.03 | 0.4 | A/G | 1.59 | GRMZM2G039757 | tolB protein-related |
| S8_150798179 | 8 | 150798179 | 5.92E-07 | 0.03 | 0.43 | A/C | −7.05 | GRMZM2G531490 | unknown |
| S10_138075442 | 10 | 138075442 | 2.75E-07 | 0.03 | 0.26 | G/C | 0.77 | GRMZM2G117667 | GDSL-like Lipase/Acylhydrolase superfamily protein |
| S10_138075445 | 10 | 138075445 | 2.75E-07 | 0.03 | 0.26 | C/T | 0.77 | GRMZM2G117668 | unknown |
| Total R2 | 24.75 | ||||||||
* is minor allele frequency, ** is minor allele effect, and MLM is mixed linear mod.