Table 3.
Analysis of BRAF V600E from ctDNA obtained from serum, plasma, CSF and original tumor.
| BRAF V600E | p Value | ||||||
|---|---|---|---|---|---|---|---|
| Patient ID | Serum ctDNA | Plasma ctDNA | CSF ctDNA | Solid Biopsy | Serum ctDNA | Plasma ctDNA | CSF ctDNA |
| LI.3 | WT | WT | WT | SN | 5.75 × 10−1 | 3.89 × 10−1 | 5.08 × 10−1 |
| LI.4 | NA | WT | MUT | WT | NA | 4.71 × 10−1 | 9.13 × 10−3 |
| LI.6 | WT | WT | NA | WT | 1 | 9.50 × 10−1 | NA |
| LI.10 | WT | MUT | NA | WT | 4.94 × 10−1 | 2.10 × 10−1 | NA |
| LI.11 | WT | MUT | WT | WT | 7.69 × 10−1 | 2.56 × 10−1 | 6.66 × 10−1 |
| LI.15 | WT | WT | SN | WT | 2.64 × 10−1 | 3.15 × 10−1 | - |
| LI.17 | WT | WT | SN | SN | 5.91 × 10−1 | 1 | - |
| LI.18 | SN | WT | NA | SN | - | 2.30 × 10−1 | NA |
| LI.21 | WT | WT | WT | SN | 5.96 × 10−1 | 6.17 × 10−1 | 8.87 × 10−1 |
| LI.22 | WT | WT | WT | WT | 7.58 × 10−1 | 9.34 × 10−1 | 9.46 × 10−1 |
| LI.23 | WT | WT | SN | SN | 3.09 × 10−1 | 5.40 × 10−1 | - |
| LI.25 | WT | WT | SN | MUT | 8.27 × 10−1 | 9.54 × 10−1 | - |
| LI.26 | WT | WT | NA | SN | 6.20 × 10−1 | 7.23 × 10−1 | NA |
| LI.28 | WT | WT | SN | SN | 5.78 × 10−1 | 9.51 × 10−1 | - |
| LI.29 | WT | WT | SN | SN | 7.74 × 10−1 | 5.98 × 10−1 | |
| LI.30 | WT | WT | WT | SN | 8.74 × 10−1 | 8.00 × 10−1 | 9.48 × 10−1 |
| LI.31 | MUT | WT | SN | MUT | 1.74 × 10−2 | 4.50 × 10−1 | - |
| LI.33 | MUT | WT | SN | SN | 4.64 × 10−3 | 2.88 × 10−1 | - |
| LI.34 | WT | WT | SN | SN | 8.47 × 10−1 | 2.93 × 10−1 | - |
| LI.35 | WT | WT | SN | SN | 3.60 × 10−1 | 1.17 × 10−1 | - |
| LI.36 | WT | MUT | SN | MUT | 3.64 × 10−1 | 6.72 × 10−4 | - |
| LI.37 | WT | WT | MUT | SN | 3.85 × 10−1 | 5.93 × 10−1 | 2.17 × 10−8 |
| LI.38 | MUT | WT | SN | MUT | 2.33 × 10−4 | 5.02 × 10−1 | - |
| LI.39 | WT | WT | SN | SN | 4.61 × 10−1 | 5.13 × 10−1 | - |
| LI.40 | WT | WT | SN | SN | 8.76 × 10−2 | 4.92 × 10−1 | - |
| LI.41 | WT | WT | SN | WT | 4.91 × 10−1 | 9.56 × 10−1 | - |
| LI.42 | WT | WT | WT | WT | 6.38 × 10−1 | 5.24 × 10−1 | 6.85 × 10−1 |
| LI.43 | WT | WT | WT | WT | 2.73 × 10−1 | 2.96 × 10−1 | 4.03 × 10−1 |
| LI.44 | WT | WT | NA | SN | 8.81 × 10−1 | 7.23 × 10−2 | NA |
NA: Not Amplified; SN: Sample Not Available.