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. 2020 Jan 17;12(1):228. doi: 10.3390/cancers12010228

Figure 2.

Figure 2

Establishment of genetic identity and stability of OTS-412. (A) Gene sequences around the point mutation (c.991 C>T) in the herpes simplex virus thymidine kinase (HSV-tk) transgene from the 1st passage and the 12th passage of OTS-412. (B) Gene sequences around the G-insertion/G-deletion mutation (c.430 7G) of the HSV-tk transgene from OTS-C1/ OTS-C2 compared to the 1st passage and the 12th passage of OTS-412. (C) HindIII restriction enzyme digestion patterns from Wyeth vaccinia virus (VACV), the 1st passage and the 12th passage of OTS-412. The arrows indicate unmatched fragments between the Wyeth VACV and OTS-412.