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. 2020 Jan 17;12(1):228. doi: 10.3390/cancers12010228

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Viral replication of OTS-412 in tumor-bearing mouse models. (A) Tumor scan using bioluminescence assay conducted two days post single-dose intratumoral (IT) injection of saline (S1), VV-tk deleted oncolytic vaccinia virus (VV^tk-) (1 × 10⁷ PFU, S2, and S3), and OTS-412 (1 × 10⁷ PFU, S4, and S5) in syngeneic RenCa tumor-bearing mice. Green diamonds (S1–S4) and red diamond (S5) in the tumor center are indicators of region of interest. (B) Quantification of the luciferase signal showing no statistical difference between the VV^tk- and OTS-412 treated mice.