Figure 4.

PTMs of TRPC5. A cartoon depicting TRPC5 with its important motifs and PTMs (those exact positions had been reported). PTMs are presented in circles. Red circles represent the reported phosphorylation sites of TRPC5, which are labeled in the format of a “p-amino acid-position”. Yellow circles represent the reported residues for S-nitrosylation and disulfide bond formation, which are labeled in the format of a “nitro/disulfi-amino acid-position”. Blue circles represent the reported residues for S-glutathionylation, which are labeled in in the format of a “gluta-amino acid-position”. The green arrows near the labels denote the PTMs decreasing the channel’s activity. The red arrows near the labels denote the PTMs which increase the channel’s activity.