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Immunohistochemical (A) and immunofluorescence double staining (B) studies using antibodies against BRCA1 and BARD1 in human tauopathies. (A) Cytoplasmic BARD1 positivity resembling tau aggregates was not observed in AD, PiD, or PSP brain samples. (B) BARD1 did not colocalize with BRCA1 in the cytoplasm and showed weak positivity in the nucleus. NFT, neurofibrillary tangle. The scale bars represent 20 µm in both A and B.
