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Liver-Specific Genetic Modification Models. (A) Cre-ER translocates into the nucleus and induces recombination between loxP sites. (B) recombinant adenovirus removes a floxed target gene. (C) doxycycline (Dox) suppresses the transcription of the gene of interest. (D) Dox activates rtTA by attaching it to the promoter and promotes the transcription of the target gene.
