Figure 2.

Schematic representation of SSX domains and their functions in regulation of PCH. All SSX proteins contain two highly conserved domains, i.e., the KRAB and SSXRD domains. KRAB domains are present in a large number of mammalian proteins and generally mediate protein interactions. In SSX molecules, this domain is essential for destabilization of 1q12 PCH, perhaps due to the recruitment of chromatin modifiers. The SSXRD domain structurally resembles C2H2 zinc finger motifs and is important for the targeting of SSX proteins to PcG-associated chromatin. Based on data from previous publications [74,88,97,98].