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. 2020 Jan 20;12(1):250. doi: 10.3390/cancers12010250

Figure 6.

Figure 6

Combined treatment of ticagrelor (Tica) and gemcitabine (GEM) reduced tumour growth in vivo. (A) Effect of different treatments on tumour weight and volume in each NOD/SCID mouse bearing BxPC-3 tumours. The significance of the difference between tumour weight and volume in mice bearing BxPC-3 tumours treated with a vehicle control or gemcitabine, ticagrelor or gemcitabine plus ticagrelor was tested using ordinary one-way ANOVA (weight) or two-way ANOVA (volume) with post-hoc Dunnett’s multiple comparison test; n = 8 for vehicle, n = 8 for gemcitabine, n = 7 for ticagrelor, n = 7 for gemcitabine plus ticagrelor. The significance of the difference between the tumour volumes was calculated using the two-way ANOVA Dunnett’s multiple comparison test to examine the significance of the mean. *** p < 0.001, * p < 0.033. (B) The level of plasma TGF-β1 in NOD/SCID mice without tumours, or age-matched NOD/SCID mice with BxPC-3 tumours treated with vehicle, gemcitabine, ticagrelor or ticagrelor plus gemcitabine (n = 4). The significance of the difference between the TGF-β1 level was calculated using the two-way ANOVA Dunnett’s multiple comparison test to examine the significance of the mean. *** p < 0.001, * p < 0.033. (C) CDD expression in BxPC-3 tumour tissues extracted from mice treated with a vehicle control, ticagrelor, gemcitabine or ticagrelor plus gemcitabine (n = 3).