Figure 1.

Micro-RNA (MiRNA)-mediated regulation of the expression of drug transporters. Rounded rectangles indicate miRNAs (light green), transcription factors (orange), cytoplasmic signaling molecules (light blue), and a transmembrane receptor (red). Activation is denoted by solid line arrows, and inhibitory effects are indicated by perpendicular lines. Dashed arrows represent the nuclear translocation of transcription factors. Several miRNAs impact the efficacy of cancer therapeutic agents by transcriptionally regulating the levels of drug transporters, as described in Section 2.3.