Table 5.
EMT-associated miRNAs and their effects on the susceptibility of cancer cells to anti-cancer treatments.
| MiRNAs | Target Gene(s) | Cancer Type | Effect of MiRNAs | Ref. |
|---|---|---|---|---|
| miR-1-3p | MET | Lung cancer | Over-expression of miR-1-3p increases the anti-proliferative effects of gefitinib | [158] |
| miR-17-5p | DEDD | Gastric cancer | Inhibition of miR-17-5p augments cisplatin- and 5-fluorouracil-induced apoptosis | [161] |
| miR-103-3p | PRKCE | Lung cancer | Enforced expression of miR-103-3p elevates the anti-proliferative effects of gefitinib along with caspase 3/7 activation | [159] |
| miR-128-3p | ZEB1 | Prostate cancer | Over-expression of miR-128-3p improves the effect of cisplatin on cell growth and invasion | [162] |
| miR-200 family | ZEB1, ZEB2 | Gastric cancer, Breast cancer | Enforced expression of miR-200 family restores trastuzumab and cyclophosphamide sensitivity in gastric and breast cancer, respectively | [163,164] |
| miR-203a-3p | SRC | Lung cancer | Enforced expression of miR-203a-3p elevates the anti-proliferative effects of gefitinib along with caspase 3/7 activation | [159] |
| miR-204-5p | TGFBR2, ZEB1 | Gastric cancer, Prostate cancer | Over-expression of miR-204-5p improves the efficacy of 5-fluorouracil in gastric cancer cells. In prostate cancer cells, miR-204-5p promotes docetaxel-mediated apoptosis | [154,165] |
| miR-206 | MET | Lung cancer | Over-expression of miR-206 increases the anti-proliferative effects of gefitinib | [158] |
| miR-363-3p | SNAI1 | Ovarian cancer | Silencing of miR-363-3p diminishes the anti-proliferative effects of cisplatin | [166] |
| miR-483-3p | ITGB3 | Lung cancer | Epigenetic silencing of miR-483-3p desensitizes cells to gefitinib | [154] |
| miR-509-5p | VIM, HMGA2 | Pancreatic cancer | Over-expression of miR-509-5p increases the anti-proliferative effects of gemcitabine | [153] |
| miR-574-3p | ZEB1 | Gastric cancer | Enforced expression of miR-574-3p elevates cisplatin-induced apoptosis | [167] |
| miR-708-3p | ZEB1, CDH2, VIM | Breast cancer | Over-expression of miR-708-3p augments doxorubicin-mediated apoptosis | [168] |
| miR-873-5p | ZEB1 | Breast cancer | Ectopic expression of miR-873-5p elevates the gemcitabine-induced cell growth arrest | [169] |
| miR-1243 | SMAD2, SMAD4 | Pancreatic cancer | Over-expression of miR-1243 increases the anti-proliferative effects of gemcitabine | [153] |