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. 2019 Dec 31;9(1):101. doi: 10.3390/cells9010101

Figure 4.

Figure 4

Cell signaling determination of artery, vein and lymph identity. COUP-TFII is one of the main determinants of vein specification. Early in differentiation, COUP-TFII, under the control of BRG-1 and ETS members (ETS-1 and ETV1), induces the expression of vein markers and represses components of the Notch pathway. Later, together with Sox18, COUP-TFII allow the expression of Prox1 and regulates lymphatic vessels differentiation. Based on References [84,85,92,93,94,95,96,97,98,99]. Redrawn from [85], published by Elsevier, 2019.