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. 2020 Jan 6;9(1):134. doi: 10.3390/cells9010134

Figure 4.

Figure 4

Effect of hypoxia and HIF1α/TET1 pathway on adipocytokine promoter methylation. Methylation-specific PCR analysis of the methylated/unmethylated ratios of leptin, IL1β, IL6, IL8, TNFα, IL17, CXCL5, MIF, VEGFA, and IFNγ in adipocytes that were cultured for 24 h under conditions of hypoxia ± CAY10585 or silenced TET1 compared to standard culturing conditions (control). Results represent the means ± SD for three independent experiments in triplicates for each treatment (n = 9). (* p < 0.05) for comparison with control and († p < 0.05) for comparison with hypoxia.