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. 2020 Jan 30;5(5):2041–2048. doi: 10.1021/acsomega.9b03764

Table 1. Use of Some Ambient Ionization Mass Spectrometry Techniques (Figure 3) for the Diagnostic Study in Humans.

technique year of inception type of diagnosis references
DESI-MS 2004 distinguishing cancer and normal specimens, determining cancer aggressiveness and grades, molecular typing of cancer, identifying cancer biomarkers, intraoperative cancer margin assessment, visualizing dermal penetration of sodium channel modulator, acquiring personal information (genders, ethnicities, and ages) from latent fingerprints. (9, 10, 12, 13, 17, 21)
PSI-MS 2010 therapeutic drug monitoring and newborn screening from dried blood spot (10, 14, 15)
TSI-MS 2014 therapeutic drug monitoring from blood, cancer diagnosis, identification of bacteria from throat swab (10, 16, 17)
EESI-MS 2006 skin and breath metabolite detection (10, 18)
REIMS/iKnife 2009 intraoperative tissue identification, classification of the tumor and healthy specimens from different organs (10, 19, 20)
MassSpec Pen 2017 rapid discrimination of cancer from normal specimens (3)
DART-MS 2005 metabolic fingerprinting and quantification (10, 22)
MALDESI-MS 2006 mapping the distribution of endogenous and exogenous (drugs) compounds in tissue specimens (23)