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. 2019 Dec 18;12(1):4. doi: 10.3390/cancers12010004

Figure 4.

Figure 4

(A) Chemical structure of mitochondria-penetrating peptides (MPPs) conjugated with anticancer drug cisplatin (mtPt), (B) cell cytotoxicity of mtPt in A2780 WT(wild type) and cisplatin-resistant A2780CP70 cell for an incubation time of 72 h showing similar cytotoxicity in both cell lines, (C) chemical structure of MPP conjugated with anticancer drug doxorubicin (mtDox), (D) cell cytotoxicity of mtDox in A2780ADR for a treatment period of 24 h showing higher cytotoxicity of mtDox compared with Dox. (Copyright permission received from reference [51] and [52]).