Figure 7.

(A) Schematic illustration of mitochondria localization induced self-assembly of peptide amphiphiles. The peptides accumulate inside the mitochondria, exceed the critical aggregation concentration (CAC), and result in the formation of nanofibers. The nanofiber interacts with the mitochondrial membrane, induces the release of proteins, apoptotic factors leading to apoptosis of the cell, (B) TEM image of nanofiber inside the mitochondria, (C) release of proteins from the mitochondria to the cytosol after treating with an intra-mitochondrially self-assembling peptide.(Copyright permission received from [73]).