Table 2.

Advantages and disadvantages of different mitochondria-targeted conventional approaches.

No.	Molecular Design	Advantages	Disadvantages
1	Conventional drug conjugate with mitochondria targeting ligand	Enhanced cell cytotoxicity	Induces toxicity towards normal cell as well
2	Photosensitizer conjugate with mitochondria targeting ligand	Quick action, higher toxicity	Induces toxicity towards normal cell as well, requires an external aid of laser for PS activation
3	Protein inhibitor conjugate with mitochondria targeting ligand	High cancer selectivity	Induces acquired resistance as a result of targeted protein mutation upon repeated administration
4	Mitochondria penetrating peptide conjugate with cargo	High mitochondria penetrating ability	Could penetrate normal cells as well, cannot be used for higher molecular weight cargo, complicated design and synthesis.