Table 3.
No. | Molecular Design | Barrier for Practical Application | Advantages for Practical Application |
---|---|---|---|
1 | Conventional drug conjugate with mitochondria targeting ligand | Fetal toxicity and side effects | - |
2 | Protein inhibitor conjugate with mitochondria targeting ligand | Complicated synthetic procedure, acquired resistance | High tumor selectivity |
3 | Mitochondria penetrating peptide conjugate with cargo | Complicated molecular design, needs to carry a cargo. | - |
4 | Mitochondria-targeted drug-free agents | - | Work at small concertation, ease of production, high selectivity towards the tumor, fewer side effects. |