Table 3.

Analysis of the possibility of different mitochondria-targeted molecules to be available for the practical application.

No.	Molecular Design	Barrier for Practical Application	Advantages for Practical Application
1	Conventional drug conjugate with mitochondria targeting ligand	Fetal toxicity and side effects	-
2	Protein inhibitor conjugate with mitochondria targeting ligand	Complicated synthetic procedure, acquired resistance	High tumor selectivity
3	Mitochondria penetrating peptide conjugate with cargo	Complicated molecular design, needs to carry a cargo.	-
4	Mitochondria-targeted drug-free agents	-	Work at small concertation, ease of production, high selectivity towards the tumor, fewer side effects.