Table 2.
Important deregulated signaling pathways after irradiation of sporadic and neurofibromatosis type 2 (NF2)-associated tumors versus controls.
| Ingenuity Canonical Pathways | Regulation | ||
|---|---|---|---|
| SPO_RAD-SPO | NF2_RAD-NF2 | SPO-NF2 | |
| Notch signaling | 1 | nr | nr |
| TGF-β signaling | 1 | nr | nr |
| Wnt/β-catenin signaling | 0 | −1 | nr |
| PTEN signaling | 0 | −1 | nr |
| IGF-1 signaling | −1 | −1 | nr |
| VEGF signaling | −1 | −1 | nr |
| cMet/HGF signaling | −1 | −1 | nr |
| ErbB2–ErbB3 signaling | −1 | −1 | nr |
| Neuregulin signaling | −1 | −1 | nr |
| EGF/EGFR signaling | 1 | −1 | nr |
| PDGF signaling | 1 | −1 | nr |
| p53 signaling | 1 | −1 | nr |
| STAT3 Pathway | 1 | −1 | 1 |
| NF-κB signaling | 1 | −1 | −1 |
| FGF signaling | 1 | −1 | −1 |
| mTOR signaling | 0 | 1 | −1 |
NF2_RAD-NF2: NF2-associated irradiated VS versus (non-irradiated) NF2-associated VS; SPO-NF2: (non-irradiated) sporadic VS versus (non-irradiated) NF2-associated VS; SPO_RAD-SPO: sporadic irradiated VS versus (non-irradiated) sporadic VS; nr = not represented in this group; 0 = no regulation change, −1 = significantly downregulated; and +1 = significantly upregulated. TGF-ß = transforming growth factor beta; Wnt/ß-catenin = proto-oncogene protein Wnt-1/beta-catenin; PTEN = phosphatase and tensin homolog; IGF-1 = insulin-like growth factor 1; VEGF = vascular endothelial growth factor; cMET = tyrosine-protein kinase Met/HGF = hepatocyte growth factor receptor; ErbB2 = receptor tyrosine-protein kinase erbB-2, aka human epidermal growth factor receptor 2, HER2; ErbB3 = receptor tyrosine-protein kinase erbB-3, aka human epidermal growth factor receptor 3, HER3; EGF/EGFR = epidermal growth factor/epidermal growth factor receptor; PDGF = platelet-derived growth factor; p53 = tumor protein p53, aka cellular tumor antigen p53; STAT3 = signal transducer and activator of transcription 3; NF-κB = nuclear factor kappa-light-chain-enhancer of activated B-cells; FGF = fibroblast growth factor; mTOR = mammalian target of rapamycin, aka mechanistic target of rapamycin.