Table 5.

Results from the Cox models for overall survival from liver metastasis.

Cohort 1 (N = 80, 80 Events)
Comparison	Hazard Ratio (#)	LL95% CI	UL95% CI	p-value
Eye Treatment to Metastasis Time (*)	0.83	0.70	0.97	0.022
Liver-directed only vs. Systemic	0.81	0.45	1.46	0.483
Liver-directed + Systemic vs. Liver-directed only	0.35	0.14	0.86	0.023
Liver-directed + Systemic vs. Systemic	0.28	0.12	0.65	0.003
Cohort 2 (N = 194, Number of Events = 193, 4 Patients with Systemic only Tx Excluded)
Comparison	Hazard Ratio (#)	LL95% CI	UL95% CI	p-value
Female vs. Male	0.65	0.48	0.87	0.003
Liver-directed + Systemic vs. Liver-directed only	0.58	0.42	0.80	0.001
Cohort 3 (N = 443, Number of Events = 365, 9 Patients with Systemic only Tx Excluded)
Comparison	Hazard Ratio (#)	LL95% CI	UL95% CI	p-value
Female vs. Male	0.75	0.61	0.93	0.003
Age 60+ vs. < 60	1.32	1.07	1.64	0.003
Liver-directed + Systemic vs. Liver-directed only				<0.001 (&)

(#) factor increase or decrease in the hazard of dying corresponding to the groups compared; (*) the reported Hazard Ratio corresponds to doubling the Eye Treatment to Metastasis Time; (&) Supremum-test of significance of time-varying coefficient in multiplicative hazard regression model. LL = Lower limit; CI = Confidence Interval; UL = Upper Limit; Tx = Treatment.