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. 2020 Jan 6;12(1):138. doi: 10.3390/cancers12010138

Figure 9.

Figure 9

DSF/Cu inhibits the growth of 5-8F xenografts via targeting cancer-associated fibroblasts. (A) The TUNEL assay on tumor biopsies. Cancer-associated fibroblasts (CAFs) and the tumor cells in the middle are shown separately. Scale bar: 100 μM. The apoptotic indices (percentages of apoptotic nuclei) are shown as means ± SD. *** p < 0.001. (B) Immunochemical staining of α-SMA in tumor tissue slices from the indicated formulation-treated groups. Scale bar: 100 μM. (C) Double immunofluorescence staining of a-SMA (red color) and TUNEL (green color) and counterstaining of chromatin with DAPI (blue color). Scale bar: 50 μM.