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Nanoparticles as a tool for the delivery of natural substances, synthetic therapeutics, and nucleic acids to revert the EMT phenotype. Schematic representation showing the effects of nanoparticles functionalized with natural substances, synthetic therapeutics, and nucleic acids, in targeting the EMT program. The resulting EMT reversion (MET) is able to limit tumor cell migration and invasion and to enhance chemosensitivity, as well as to reduce tumor growth.
