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. 2019 Dec 6;214(2):333–354. doi: 10.1534/genetics.119.302754

Figure 5.

Figure 5

Formation of amplifications in unstable revertants Most unstable revertants are initiated by pre-existing cells that carry multiple copies of a plasmid with a tandem duplication of the mutant lac region. Other duplications may form under selection during transfer between standard initiator daughter cells. Transfer of a duplication-bearing plasmid provides conditions for unequal recombination that can expand the tandem array of lac copies.