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Recombinant GDF3 protein attenuates inflammatory response and mortality in endotoxin-induced septic mice. WT mice injected with rGDF3 protein (I.P., 10μg/kg BW) 12 h prior to LPS injection (I.P., 10mg/kg BW), 12 h later serum was collected for measuring (A) TNF-α, (B) IL-6, and (C) MCP-1 levels (*, p < 0.05 vs. Ctl; #, p < 0.05 vs. LPS + B; n = 5). (D) Kaplan-Meier survival curves were generated for LPS-mice treated with or without rGDF3 (*, p < 0.05; n = 12).
