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. 2019 Dec 20;9(1):31. doi: 10.3390/cells9010031

Figure 1.

Figure 1

Effects of eltrombopag on human cytomegalovirus (HCMV) late antigen (LA) expression in primary human foreskin fibroblasts (HFFs). (A) Representative dose–response curves showing the effects of eltrombopag on HCMV LA expression and HFF viability (as determined after 120 h of incubation). Eltrombopag concentrations that reduce HCMV LA expression by 50% (inhibitory concentration (IC)50) or 90% (IC90) and cell viability by 50% (cytotoxicity concentration (CC)50) relative to untreated controls are also provided. Eltrombopag was continuously present from the time of virus infection. (B) Representative photographs and Western blots demonstrating the effects of eltrombopag on HCMV LA expression. In (A,B), HFFs were infected with HCMV strain Hi91 (multiplicity of infection (MOI) 0.02). HCMV LA expression was detected 120 h post infection. (C) Representative dose–response curves and IC50 values indicating effects of eltrombopag on HCMV LA expression in HFFs infected with different MOIs of HCMV strain Hi91 as detected 120 h post infection.