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. 2020 Jan 1;12(1):111. doi: 10.3390/cancers12010111

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Analysis of mRNA levels of sphingolipid metabolic enzymes in GBM patients from publicly available Rembrandt and Cancer Genome Atlas brain cancer datasets show small but significant differences in gene expression compared to the normal brain. Rembrandt dataset (n = 214). TCGA dataset (n = 169), which can be subdivided into Classical (n = 54), Mesenchymal (n = 58) and Proneural (n = 57) molecular subtypes. White boxes indicate genes which are not significantly differentially expressed (p > 0.05). Grey boxes indicate genes for which complete data were not available. Other genes involved in sphingolipid metabolism for which no data were available were: Ceramide synthases 1-6 (CERS1-6), Alkaline ceramidase 2 (ACER2), Acid sphingomyelinase (SPMD1), Neutral sphingomyelinases 1 and 2 (SPMD2 and SPMD3), Lipid phosphate phosphatases 1-3 (PLPP1-3), and Serine palmitoyltransferase, subunit 1 (SPTLC1).