Skip to main content
. 2019 Dec 18;9(1):11. doi: 10.3390/cells9010011

Figure 4.

Figure 4

Effect of IL-18Rα on the production of inflammatory cytokines after collagen-induced arthritis (CIA). Serum tumor necrosis factor (TNF), interferon (IFN)-γ, IL-6, IL-12p40, IL-18, and matrix metalloproteinase-3 (MMP-3) productions were measured as biomarkers of arthritis on days 2 (n = 12 and n = 8), 4 (n = 10 and n = 15), and 14 (n = 8 and n = 6) in wild-type (WT) and IL-18Rα KO mice after lipopolysaccharide (LPS) injection. Dotted lines represent mean values from normal DBA1/J mice without bovine type II collagen and LPS injection. The data are mean ± SEM. * p < 0.05, ** p < 0.01, WT vs. IL-18Rα KO mice.