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. 2020 Jan 9;12(1):161. doi: 10.3390/cancers12010161

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Treatment effects of free CYP, CYP-loaded CA NPs, and drug-free CA NPs compared to the untreated group of mice. Tumor picture was taken at day 27 after the mice were sacrificed humanely via euthanasia. Values were significant (*) at a p-value of 0.01 to 0.05, very significant (**) at a p-value of 0.001 to 0.01, highly significant (***) at a p-value of 0.0001 to 0.001, and extremely significant (****) at a p-value < 0.0001 vs. the same treatment with free CYP at a confidence interval (CI) of 95%.