Table 2.
Multivariate Cox regression for cancer-specific survival in the TCGA cohort (n = 409) and the validation cohort (n = 51).
| Multivariate Analyses | Variable | Level |
p-Value (Wald Test) |
HR (95% CI) |
|---|---|---|---|---|
| Including T, N, M, G and OSM score | OSM score | 2.35 × 10−5 | 2.6 (1.67–3.69) | |
| (TCGA cohort) | Primary tumor | T1/T2 | 1 | |
| T3/T4 | 5.05 × 10−2 | 1.7 (1–2.86) | ||
| Lymph nodes | N0 | 1 | ||
| N1 | 6.15 × 10−2 | 2.71 (0.95–7.72) | ||
| NX | 2.4 × 10−2 | 0.6 (0.38–0.93) | ||
| Distant metastasis | M0 | 1 | ||
| M1 | 1.55 × 10−12 | 5.62 (3.48–9.07) | ||
| Grade | G1/G2 | 1 | ||
| G3/G4 | 6.69 × 10−3 | 2.35 (1.27–4.37) | ||
| Including T, N, M, G and OSM score | OSM score | 1.58 × 10−2 | 1.34 (1.06–1.7) | |
| (Validation cohort) | Primary tumor | T1/T2 | 1 | |
| T3/T4 | 2.54 × 10−1 | 2.63 (0.5–13.9) | ||
| Lymph nodes | N0 | 1 | ||
| N1/N2 | 1.27 × 10−1 | 0.33 (0.08–1.36) | ||
| Distant metastasis | M0 | 1 | ||
| M1 | 2.78 × 10−5 | 41 (7.22–233.06) | ||
| Fuhrman grade | G1/G2 | 1 | ||
| G3/G4 | 9.94 × 10−1 | 1 (0.29–3.43) |
Abbreviations: CI, confidence interval; HR, hazard ratio; Ref., reference level; T, primary tumor; N, regional lymph node; M, distant metastasis present at diagnosis; G, grading. Cases with grading information “GX” or metastasis status “MX” were excluded from multivariate analyses. OSM scores were determined based on gene expression data measured by RNA-Seq (TCGA) or microarray analyses (validation cohort).