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. 2020 Jan 12;12(1):186. doi: 10.3390/cancers12010186

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of tivantinib on the ATPase activity of ABCG2 and accumulation of [³H]-mitoxantrone. (A) Tivantinib stimulates the ATPase activity of the ABCG2 transporter; (B) The effect of tivantinib on the intracellular accumulation of [³H]-mitoxantrone in NCI-H460 and NCI-H460/MX20 cells after 2 h treatment. Data are expressed as the mean ± SD from a representative of three independent experiments. * p < 0.05, compared with control group.