| Methods |
Randomized |
| Participants |
Adults (mean age: 58)
Severe bacterial respiratory tract infection (34/122 presumed bacterial, no isolation)
CAP + nursing home‐acquired + nosocomial |
| Interventions |
Atypical: IV ciprofloxacin 200 mg X 2/d (5 patients received 300 mg X 2/d)
Non‐atypical: IV ceftazidime 1 to 2 G X 2/d to 3/d |
| Outcomes |
Failure = continuation/worsening of signs and symptoms |
| Notes |
Distribution of nosocomial pneumonia versus CAP unclear; good results suggest low rate of nosocomial pneumonia |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Antibiotics were administered with a computer‐generated, randomized code |
| Allocation concealment (selection bias) |
Low risk |
Antibiotics were administered in a sequential manner |
| Incomplete outcome data (attrition bias)
Mortality |
High risk |
122/140 patients evaluated |
| Incomplete outcome data (attrition bias)
Failure |
High risk |
122/140 patients evaluated |
| Selective reporting (reporting bias) |
Low risk |
Not identified |
| Other bias |
Unclear risk |
Manufacturer/Pharmaceutical company sponsored |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
None |
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
None |
