Kohno 2011.
Methods | Randomized, open‐label, non‐inferiority study Multicenter |
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Participants | Adults (mean age: 58.5) CAP mild to severe (70% moderate) | |
Interventions | Atypical: IV levofloxacin 500 mg X 1/d for 7 to 14 days Non‐atypical: IV ceftriaxone 1 G X 2/d for 7 to 14 days | |
Outcomes | Success: clinical, radiological and laboratory | |
Notes | Study in Japanese | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Low risk | Central, registration control system |
Allocation concealment (selection bias) | Low risk | Evaluator center, randomly allocated patients |
Incomplete outcome data (attrition bias) Mortality | High risk | 200/260 patients evaluated |
Incomplete outcome data (attrition bias) Failure | High risk | 200/260 patients evaluated |
Selective reporting (reporting bias) | Low risk | Not identified |
Other bias | Low risk | Not identified |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Open label trial |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | A separate party committee evaluated the effects of the drugs, not knowing which drug had been used |