Lephonte 2004.
| Methods | Randomized Multicenter | |
| Participants | Adults (mean age: 54) CAP Suspected pneumococcal pneumonia > 90% hospitalized | |
| Interventions | Atypical: PO gemifloxacin 320 mg X 1/d for 1 week Non‐atypical: amoxicillin/clavulanate 1 G/125 mg X 3/d for 10 days | |
| Outcomes | Failure = clinical, bacteriological and radiological | |
| Notes | Phase III Suspected pneumococcal pneumonia | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Not described |
| Allocation concealment (selection bias) | Unclear risk | Not described |
| Incomplete outcome data (attrition bias) Mortality | High risk | 249/324 patients evaluated |
| Incomplete outcome data (attrition bias) Failure | High risk | 249/324 patients evaluated |
| Selective reporting (reporting bias) | Low risk | Not identified |
| Other bias | Unclear risk | Manufacturer/Pharmaceutical company sponsored No ITT analysis |
| Blinding of participants and personnel (performance bias) All outcomes | Low risk | Double‐blind |
| Blinding of outcome assessment (detection bias) All outcomes | Low risk | Double‐blind |