| Methods |
Randomized
Multicenter |
| Participants |
Adults (mean age: 54)
Hospitalized and outpatients
CAP |
| Interventions |
Atypical: PO sparfloxacin 400 mg loading dose, followed by PO sparfloxacin 200 mg X 1/d
PO erythromycin 1 G X 2/d
Non‐atypical: PO amoxicillin‐clavulanic acid 500/125 mg X 3/d |
| Outcomes |
Failure = clinical, radiological, change of antibiotics
Modification = failure |
| Notes |
3 arms in 2:1:1 randomizations (sparfloxacin: amoxicillin‐clavulanic acid: erythromycin); the two atypical arms were calculated as one, in comparison to the non‐atypical arm
Note: also outpatients ‐ no further data, short of stating the majority of patients were hospitalized |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Not described |
| Allocation concealment (selection bias) |
Unclear risk |
Not described |
| Incomplete outcome data (attrition bias)
Mortality |
Low risk |
All patients evaluated |
| Incomplete outcome data (attrition bias)
Failure |
Low risk |
All patients evaluated |
| Selective reporting (reporting bias) |
Low risk |
Not identified |
| Other bias |
Unclear risk |
Sponsored |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
Double‐blind |
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
Double‐blind |
