Norrby 1998.

Methods	Randomized Multicenter
Participants	Adults (mean 65) Hospitalized Pneumonia (CAP 94%; nosocomial 6%)
Interventions	Atypical: IV levofloxacin 500 mg X 2/d, followed by PO levofloxacin 500 mg X 2/d Non‐atypical: IV ceftriaxone 4 G X 1/d
Outcomes	Cure = all infection related signs and symptoms disappeared or returned to pre‐infection state and chest X‐ray findings at least improved Failure = all infection related signs and symptoms unchanged or worsened; patients developed new clinical findings consistent with active infection; patient died due to the infection; drug study discontinued; one or more antibiotics added to drug due to treatment failure
Notes	CAP and nosocomial infection
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Central, computerized telephone system
Allocation concealment (selection bias)	Low risk	Evaluator‐blinded for selected patients
Incomplete outcome data (attrition bias) Mortality	High risk	619/625 patients evaluated
Incomplete outcome data (attrition bias) Failure	High risk	619/625 patients evaluated
Selective reporting (reporting bias)	Low risk	Not identified
Other bias	Unclear risk	Sponsored No ITT
Blinding of participants and personnel (performance bias) All outcomes	High risk	None
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Three types of assessments were performed according to the study protocol: protocol, conducted by computer; investigator, conducted by the investigator and evaluator‐blinded, conducted by an external evaluator for selected patients using blinded data