| Methods |
Randomized |
| Participants |
Adults > 60 years old (mean: 81 years)
Nursing home residents
Hospitalized
CAP/RTI |
| Interventions |
Atypical: PO ciprofloxacin 750 mg X 2/d
Non‐atypical: IM cefamandole 1 G X 4/d |
| Outcomes |
Success = improvement in signs and symptoms and patient not given another course of drug treatment for RTI within 6 weeks of discharge |
| Notes |
2/3 CAP, 1/3 RTI, most data combined |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Computer‐generated random assignment code |
| Allocation concealment (selection bias) |
Low risk |
Sealed envelopes |
| Incomplete outcome data (attrition bias)
Mortality |
Low risk |
All patients evaluated |
| Incomplete outcome data (attrition bias)
Failure |
Low risk |
All patients evaluated |
| Selective reporting (reporting bias) |
Low risk |
Not identified |
| Other bias |
Unclear risk |
Sponsored |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
None |
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
None |
