| Methods |
Randomized
Multinational, multicenter |
| Participants |
Adults (mean age: 51)
CAP: suspected pneumococcal pneumonia
79% hospitalized |
| Interventions |
Atypical: PO moxifloxacin 400 mg X 1/d
Non‐atypical: PO Amoxicillin 1 G X 3/d
Both for 10 days |
| Outcomes |
Clinical response
Failure = insufficient resolution of symptoms/death |
| Notes |
Presumed pneumococcal pneumonia |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Low risk |
Author confirmed in correspondence adequate methods |
| Allocation concealment (selection bias) |
Low risk |
Author confirmed in correspondence adequate methods |
| Incomplete outcome data (attrition bias)
Mortality |
High risk |
408/411 patients evaluated |
| Incomplete outcome data (attrition bias)
Failure |
High risk |
408/411 patients evaluated |
| Selective reporting (reporting bias) |
Low risk |
Not identified |
| Other bias |
Unclear risk |
Sponsored |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
Double‐blind |
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
Double‐blind |
