| Methods |
Randomized
Multicenter |
| Participants |
Adults > 16 years old (mean age: 52)
75% hospitalized
CAP: exclusion: high probability of atypical pneumonia |
| Interventions |
Atypical: PO trovafloxacin 200 mg X 1/d
Non‐atypical: PO amoxicillin 1 G X 3/d |
| Outcomes |
Primary = clinical response; Secondary = bacteriological response
Failure = lack of resolution of signs and symptoms/radiological failure/additional ABX given to patient |
| Notes |
Adult defined as age > 16 years old (rather than 18 years old, as in other studies)
Only 75% hospitalized |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Not described |
| Allocation concealment (selection bias) |
Unclear risk |
Not described |
| Incomplete outcome data (attrition bias)
Mortality |
High risk |
335/344 patients evaluated |
| Incomplete outcome data (attrition bias)
Failure |
High risk |
285/344 patients evaluated |
| Selective reporting (reporting bias) |
Low risk |
Not identified |
| Other bias |
Unclear risk |
Sponsored |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
Double‐blind |
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
Double‐blind |
