| Methods |
Randomized
Multicentre |
| Participants |
Adults (mean 60)
Severe bronchopulmonary infections
Hospitalized |
| Interventions |
Atypical: PO pefloxacin 400 mg X 2/d
Non‐atypical: IV ceftazidime 2 G X 2/d |
| Outcomes |
Success not defined in study
Bacteriological outcome |
| Notes |
Severe infection = failure on previous treatment, multi‐resistant pathogens, severe underlying disease, poor general condition |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
Not identified |
| Allocation concealment (selection bias) |
Unclear risk |
Not identified |
| Incomplete outcome data (attrition bias)
Mortality |
Low risk |
All patients evaluated |
| Incomplete outcome data (attrition bias)
Failure |
High risk |
156/170 patients evaluated |
| Selective reporting (reporting bias) |
Low risk |
Not identified |
| Other bias |
Unclear risk |
Unknown sponsorship |
| Blinding of participants and personnel (performance bias)
All outcomes |
High risk |
None |
| Blinding of outcome assessment (detection bias)
All outcomes |
High risk |
None |
