Zeluff 1988.

Methods	Randomized
Participants	Adults (mean age: 31; all South‐African black gold miners) Hospitalized Pneumococcal pneumonia per chest X‐ray and sputum (analyzed only culture positive)
Interventions	Atypical: PO roxithromycin 150 mg X 2/d Non‐atypical: PO cephradine 1 G X 2/d
Outcomes	Clinical response (= improvement of signs and symptoms and resolution of lung infiltrate)
Notes	Pneumococcal pneumonia in a young homogenous group
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	An allocation schedule of random numbers
Allocation concealment (selection bias)	Unclear risk	Not identified
Incomplete outcome data (attrition bias) Mortality	High risk	158/160 participants evaluated
Incomplete outcome data (attrition bias) Failure	High risk	90/160 participants evaluated
Selective reporting (reporting bias)	Low risk	Not identified
Other bias	Unclear risk	? sponsored
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blind
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Double‐blind

ABX: antibiotics 
 CAP: community‐acquired pneumonia 
 COPD: chronic obstructive pulmonary disease 
 IM: intramuscular 
 ITT: intention‐to‐treat 
 IV: intravenous 
 LD: loading dose 
 PO: per oral 
 RTI: respiratory tract infection 
 s/e: side effects 
 1/d: once a day 
 2/d: two times a day 
 3/d: three times a day 
 4/d: four times a day