Figure 4.

Mitochondrial fusion dysfunction inhibited tumor formation and growth in vivo. (A) Huh7 shOPA1 and control cells were injected subcutaneously into nude mice. Tumor size was measured at post-injection days 1/17/19/24/27 (n = 4 pairs). Huh7 shMFN1 and control cells were injected and tumor size was measured in the same way (n = 5 pairs). (B) Tumors were harvested from nude mice at day 27 and weighed. Histograms show means ± SEM with p value derived by the Mann Whitney test.