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. 2020 Jan 1;12(1):114. doi: 10.3390/cancers12010114

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Optic pathway glioma and a high-grade cerebellar glioma in a young adult with NF1. (A) MRI brain, axial T2 sequence showing hyperintense left optic nerve lesion (arrow) and ill-defined hyperintense lesion within the left cerebellum (asterisk) associated with mass effect. (B) Post-contrast T1 sequence showing heterogeneous enhancement of the left cerebellar lesion concerning high grade neoplasm (asterisk). Histopathologic evaluation of the left cerebellar lesion was consistent with glioblastoma, WHO grade IV, IDH wild-type (C) Infiltrating glioma exhibiting atypical cells and vascular endothelial proliferation (H&E, 200×). (D) Tumor cells are negative for IDH1 (R132H) mutant protein (IHC, 200×).