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. 2019 Dec 23;11(1):18. doi: 10.3390/genes11010018

Figure 2.

Figure 2

Vulpinic acid promotes the expression of Wnt genes via H3 acetylation in 10T1/2 MSCs. (A) Schematic representation of Wnt signaling-mediated cell fate determination of mesenchymal stem cells (MSCs). (B) The mRNA levels of Wnt6, Wnt10a, and Wnt10b genes in 10T1/2 cells treated with vulpinic acid (10 or 40 μM) for 24 h. (C) 10T1/2 cells were treated with or without vulpinic acid (40 μM) for 24 h. ChIP assay was performed with IgG and acetylated H3 antibodies followed by real time PCR with primers for promoter regions of Wnt6, Wnt10a, and Wnt10b genes. Data represent means ± SEM for n = 3. * p < 0.05, ** p < 0.01, *** p < 0.001.