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Molecular model underlying the mechanism of actions of vulpinic acid. During the early stage of mesenchymal stem cells, vulpinic acid promotes osteogenic commitment while preventing adipogenic commitment via H3 acetylation-mediated gene modulations. During terminal differentiation to mature adipocytes from preadipocytes, vulpinic acid enhances de novo generation of adipocytes via acetylation of α-tubulin, reducing hypertrophic adipocytes.
