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. 2019 Dec 19;12(1):22. doi: 10.3390/cancers12010022

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Expression of IF1 in human colon carcinomas. (A) Representative staining of IF1 expression in normal and tumor tissue of the colon. Magnification 25x. (B) Western blots show IF1 and β-F1-ATPase (β-F1) in paired normal (N) and tumor (T) biopsies derived from three representative patients and increasing amounts of the recombinant IF1 (r-IF1) protein (0–200 ng). Linear correlations between the fluorescence intensity (arbitrary units) of the spots and the amount of recombinant protein. The histogram shows significant differences in the expression of IF1 between the two groups of samples. Protein concentration was calculated according to the fluorescence intensity obtained in r-IF1 plot. The results shown are mean ± S.E.M; *, p < 0.05 when compared to its respective control. (C) Kaplan–Meier curves for disease-free survival probability for the cohort of 37 colon cancer patients stratified by the tumor expression level of IF1. The log-rank test p-value (p < 0.0004) is shown.