Figure 8.

Histological features of the treated tumors. (a) Non-treated Ehrlich carcinoma. The invasive tumor has a solid structure composed of atypical cells with pleomorphic, hyperchromatic nuclei of different shapes and volume and grows into the muscle tissue. No immune response. (b) Treated with an aptamer mix. Carcinoma cells are with cytoplasm vacuolization; lymphocytic infiltration is moderate. (c,d) FrFeAG and LFAMF treated carcinoma has scattered tumor necrosis among the remaining carcinoma tissue with inflammatory infiltration around them. (e,f) AS-FrFeAG in LFAMF caused irreversible damaging effects on the treated tumor, such as karyo and plasmolysis, and karyo and plasmorrhexis. Large tumor necrosis area, on the periphery of which remains small amounts of dead carcinoma cells with destructive changes of the cancer tissue microenvironment. Visible inflammatory infiltration of segmented leukocytes and swellings observed. Magnification × 100.