Table 2.
Dose dependent Wald ORs relative to no exposure.
| Cases | Controls | |||||
|---|---|---|---|---|---|---|
| Exposure | Dose | n (%) | n (%) | OR | 95% CI | p-Value |
| Acetaminophen | None | 54 (5.4) | 45 (8.8) | Reference | ||
| 1–3 | 174 (17.4) | 91 (17.7) | 1.593 | 0.996–2.549 | 0.0511 | |
| 4–15 | 378 (37.8) | 216 (42.0) | 1.458 | 0.949–2.241 | 0.0839 | |
| 16–63 | 191 (19.1) | 107 (20.8) | 1.488 | 0.938–2.359 | 0.0904 | |
| 64+ | 26 (2.6) | 4 (0.8) | 5.417 | 1.759–16.68 | 0.0015 * | |
| Not sure | 178 (17.8) | 51 (9.9) | - | - | - | |
| Ibuprofen | None | 185 (18.5) | 115 (22.4) | Reference | ||
| 1–3 | 167 (16.7) | 91 (17.7) | 1.141 | 0.808–1.612 | 0.4549 | |
| 4–15 | 304 (30.4) | 180 (35.0) | 1.050 | 0.780–1.413 | 0.7481 | |
| 16–63 | 141 (14.1) | 74 (14.4) | 1.184 | 0.822–1.706 | 0.3634 | |
| 64+ | 17 (1.7) | 6 (1.2) | 1.761 | 0.675–4.597 | 0.2422 | |
| Not sure | 187 (18.7) | 48 (9.3) | - | - | - | |
| Acetaminophen in males | None | 37 (4.6) | 20 (7.5) | Reference | ||
| 1–3 | 134 (16.7) | 52 (19.4) | 1.393 | 0.741–2.619 | 0.3023 | |
| 4–15 | 308 (38.5) | 110 (41) | 1.514 | 0.842–2.719 | 0.1634 | |
| 16–63 | 156 (19.5) | 55 (20.5) | 1.533 | 0.821–2.864 | 0.1782 | |
| 64+ | 21 (2.6) | 2 (0.7) | 5.676 | 1.206–26.72 | 0.0167 * | |
| Not sure | 145 (18.1) | 29 (10.8) | - | - | - | |
| Ibuprofen in males | None | 147 (18.4) | 61 (22.8) | Reference | ||
| 1–3 | 126 (15.7) | 47 (17.5) | 1.112 | 0.740–1.742 | 0.6415 | |
| 4–15 | 245 (30.6) | 83 (31) | 1.225 | 0.830–1.807 | 0.3060 | |
| 16–63 | 118 (14.7) | 44 (16.4) | 1.113 | 0.705–1.758 | 0.6465 | |
| 64+ | 13 (1.6) | 3 (1.1) | 1.798 | 0.495–6.535 | 0.3668 | |
| Not sure | 152 (19) | 30 (11.2) | - | - | - | |
| Acetaminophen in females | None | 17 (8.5) | 25 (10.2) | Reference | ||
| 1–3 | 40 (20) | 39 (15.9) | 1.508 | 0.707–3.218 | 0.2866 | |
| 4–15 | 70 (35) | 106 (43.1) | 0.971 | 0.489–1.929 | 0.9333 | |
| 16–63 | 35 (17.5) | 52 (21.1) | 0.990 | 0.467–2.097 | 0.9787 | |
| 64+ | 5 (2.5) | 2 (0.8) | 3.677 | 0.638–21.19 | 0.1274 | |
| Not sure | 33 (16.5) | 22 (8.9) | - | - | - | |
| Ibuprofen in females | None | 38 (19) | 54 (22) | Reference | ||
| 1–3 | 41 (20.5) | 44 (17.9) | 1.324 | 0.731–2.399 | 0.3541 | |
| 4–15 | 59 (29.5) | 97 (39.4) | 0.864 | 0.511–1.463 | 0.5871 | |
| 16–63 | 23 (11.5) | 30 (12.2) | 1.089 | 0.550–2.158 | 0.8059 | |
| 64+ | 4 (2) | 3 (1.2) | 1.895 | 0.401–8.957 | 0.4137 | |
| Not sure | 35 (17.5) | 18 (7.3) | - | - | - | |
Notes: * for p values < 0.05. Abbreviations: OR, Wald odds ratio; 95% CI, 95% Wald confidence interval.