Table 1.
Clinical features of the TCGA HNSCC cohort stratified by rs6942067 status.
| Characteristics | rs6942067 (AA/AG) | rs6942067 (GG) | p |
|---|---|---|---|
| Total | 131 | 23 | |
| Age group, n (%) | 0.12 | ||
| ≥40 years old | 125 (95.4) | 19 (82.6) | |
| <40 years old | 6 (4.6) | 4 (17.4) | |
| Gender, n (%) | 0.43 | ||
| Female | 38 (29.0) | 4 (17.4) | |
| Male | 93 (71.0) | 19 (82.6) | |
| Anatomical subsite, n (%) | 0.88 | ||
| Oral tongue | 47 (35.9) | 8 (34.8) | |
| Other oral cavity | 42 (32.1) | 6 (26.1) | |
| Oropharynx | 23 (17.6) | 4 (17.4) | |
| Larynx and hypopharynx | 19 (14.5) | 5 (21.7) | |
| Smoking status, n (%) | 0.14 | ||
| Current/previous ≥ 10 PY 1 | 99 (75.6) | 13 (56.5) | |
| Never/previous < 10 PY 1 | 32 (24.4) | 10 (43.5) | |
| HPV, n (%) | 0.59 | ||
| Positive | 33 (25.2) | 4 (17.4) | |
| Negative | 98 (74.8) | 19 (82.6) | |
| Tumor size, n (%) | 0.88 | ||
| T1-2 | 53 (40.5) | 9 (39.1) | |
| T3+ | 77 (58.8) | 14 (60.9) | |
| Tx, unknown | 1 (0.8) | 0 (0) | |
| Nodal status, n (%) | 0.12 | ||
| N0 | 64 (48.9) | 6 (26.1) | |
| N+ | 64 (48.9) | 17 (73.9) | |
| Nx, unknown | 2 (1.5) | 0 (0) |
1 Pack-year.